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Genomics [NBC] PDF Print E-mail
neuroscience_blueprint.jpg A completely sequenced and highly annotated human genome has greatly enhanced the resources available for scientists to better understand the molecular and genetic basis of human pathophysiology. Some of the first disease-gene associations were identified in diseases of the nervous system such as Alzheimer’s disease, Huntington’s chorea and Fragile X mental retardation.

Facilities/Services:

The Genomics Core is comprised of multiple facilities which provide services to investigators at Washington University.

Multiplexed Gene Analysis (SCC-MGA) Core

This facility, initiated in 1999 by the Siteman Cancer Center, uses the Affymetrix GeneChip platform to perform microarray-based gene expression profiling in human and model organisms samples, and array-based human SNP genotyping assays.

Human Genetics Genotyping Core

This facility uses the Sequenom mass array spectrometry system for high performance SNP genotyping in any organism. It produces high quality data from large numbers of samples arrayed in 384-well plates and allows custom genotyping of up to 20-plexed SNPs within candidate genes or genomic intervals.

Laboratory of Clinical Genomics (LCG)

Recently developed under the auspices of the Division of Laboratory Medicine, this shared resource facility is designed to perform moderate throughput DNA resequencing of candidate genes in clinical samples.

The Genome Sequencing Center (GSC)

The GSC was responsible for a large percentage of the recently completed Human Genome Project and is now performing high throughput sequencing projects with patient materials.

Staff/Contacts

  • This email address is being protected from spam bots, you need Javascript enabled to view it , Core Director
  • Alison Goate, Co-Director
  • Shelly Audrain, Senior Research Technician
  • Melanie Behlmann, Senior Research Technician

Support/Acknowledgements

This Core is is supported by a Neuroscience Blueprint Core grant (P30 NS057105) from NIH to Washington University.