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Hope Center Faculty

 Robert H. Baloh, M.D., Ph.D.
Assistant Professor of Neurology

Neurodegenerative diseases of the peripheral nervous system

 Randall Bateman, M.D.
Assistant Professor of Neurology

Alzheimer's disease: Pathophysiology, biomarkers, predictive diagnostics and treatments

 Philip V. Bayly, Ph.D.
Hughes Professor of Mechanical Engineering; Professor of Biomedical Engineering

Biomechanical factors in traumatic injury to the brain and spinal cord

 David L. Brody, M.D., Ph.D.
Assistant Professor of Neurology

Translational research in traumatic brain injury

 Janice E. Brunstrom, M.D.
Associate Professor of Neurology and Pediatrics; Director of the Pediatric Neurology Cerebral Palsy Center at St. Louis Children's Hospital

Motor disorders arising from injury to the developing brain

 Guojun Bu, Ph.D.
Professor of Pediatrics and Cell Biology & Physiology

LDL receptor family members in human disease

 Nigel Cairns, Ph.D., MRCPath
Research Associate Professor of Neurology and Pathology & Immunology; Director, Betty Martz Laboratory for Neurodegenerative Research

Protein misfolding, inclusion formation and neurodegeneration in Frontotemporal Dementias

 Valeria Cavalli, Ph.D.
Assistant Professor of Anatomy and Neurobiology

Axonal Transport, Injury Signaling and Nerve Regeneration

 Anne H. Cross, M.D.
Professor of Neurology; Manny and Rosalyn Rosenthal and Dr. John Trotter MS Center Chair in Neuroimmunology; Director, Multiple Sclerosis Center

Neuroimmunology related to multiple sclerosis

 C. Michael Crowder, M.D., Ph.D.
Associate Professor of Anesthesiology and Developmental Biology

Fundamental mechanisms of neuronal cell death following hypoxic injury

 Ralph G. Dacey, Jr., M.D.
Henry G. and Edith R. Schwartz Professor and Chair of Neurological Surgery

Regulation of coagulation

 Aaron DiAntonio, M.D., Ph.D.
Associate Professor of Developmental Biology

Mechanisms of synaptic structure and function during development

 Hans H. Dietrich, Ph.D.
Research Assistant Professor of Neurological Surgery

Regulatory mechanisms of cerebrovascular microcirculation

 Alex S. Evers, M.D.
Henry E. Mallinckrodt Professor and Head of Anesthesiology; Professor of Internal Medicine and Developmental Biology

Molecular mechanisms of anesthetics in the nervous system

 Anne M. Fagan Niven, Ph.D.
Research Associate Professor of Neurology

Biomarkers, and mechanisms of apoE4 action in Alzheimer's Disease

 Carl Frieden, Ph.D.
Professor of Biochemistry & Molecular Biophysics

Protein folding, structure

 James E. Galvin, M.D., M.P.H.
Assistant Professor of Neurology

Clinical and pathological correlates of neurodegenerative disease

 Jeffrey M. Gidday, Ph.D.
Associate Professor of Neurological Surgery

Endogenous mechanisms of vascular and parenchymal protection in CNS ischemia.

 Alison M. Goate, D.Phil.
Samuel and Mae S. Ludwig Chair in Psychiatry; Professor of Neurology and Genetics; Hope Center Steering Committee

Linkage and association studies to uncover genetic susceptibility to neuropsychiatric disease.

 Mark P. Goldberg, M.D.
Professor of Neurology, Neurobiology, and Biomedical Engineering; Director of the Hope Center for Neurological Disorders

Mechanisms of ischemic injury and recovery in white matter axons and glia.

 Christina Gurnett, M.D., Ph.D.
Assistant Professor of Neurology

Genetic basis of epilepsy

 Phyllis I. Hanson, M.D., Ph.D.
Associate Professor of Cell Biology and Physiology

Protein-protein and protein-membrane interactions in neuronal membrane trafficking.

 David A. Harris, M.D., Ph.D.
Professor of Cell Biology and Physiology

Cellular and molecular biology of prion diseases.

 Erik D. Herzog, Ph.D.
Associate Professor of Biology

Molecular mechanism of circadian rythms

 Robert O. Heuckeroth, M.D., Ph.D.
Associate Professor of Pediatrics

Molecular mechanisms of neuronal development

 David M. Holtzman, M.D.
Andrew B. and Gretchen P. Jones Professor and Chairman of Neurology; Professor of Molecular Biology; Hope Center Steering Committee

Cellular/Molecular/Biomarkers studies of Alzheimer’s disease and neonatal brain injury.

 Mark Jacquin, Ph.D.
Professor of Neurology

Molecular mechanisms of mammalian sensory system development, plasticity and repair.

 Sanjay Jain, M.D., Ph.D.
Assistant Professor of Internal Medicine

GFL-Ret mediated mechanisms in the development, repair and regeneration of the nervous and urogenital systems

 Eugene M. Johnson, Ph.D.
Professor of Neurology and Developmental Biology; Hope Center Steering Committee

Biological function and pharmacological potential of GFL neurotrophic factors

 Robyn S. Klein, M.D., Ph.D.
Assistant Professor of Internal Medicine

Molecular basis of inflammation-associated dysfunction in viral and autoimmune encephalitides

 Raphael Kopan, Ph.D.
Professor of Internal Medicine and Developmental Biology

Studies of cell fate determination in mammalian system with focus on Notch mediated signal transduction.

 Paul T. Kotzbauer, M.D., Ph.D
Assistant Professor of Neurology

Mechanisms of neurodegeneration in Parkinson's disease and related disorders.

 Jin-Moo Lee, M.D., Ph.D.
Associate Professor of Neurology

Understanding the molecular pathogenesis of spontaneous intracerebral hemorrhage

 Mingjie Li, M.D., Ph.D.
Research Assistant Professor of Neurology

 Susan Mackinnon, M.D.
Shoenberg Professor, Chief, Division of Plastic and Reconstructive Surgery

 Steven J. Mennerick, Ph.D.
Associate Professor of Psychiatry and Anatomy & Neurobiology

Physiology of glutamate and GABA neurotransmission in the CNS.

 Jeffrey D. Milbrandt, M.D., Ph.D.
David Clayson Professor of Neurology; Professor of Pathology & Immunology and Internal Medicine; Hope Center Steering Committee

Axonal degeneration, regulation of myelination, neuronal energetics and mitochondrial function in neuropathy and neurodegenerative disease

 Timothy M. Miller, M.D., Ph.D.
Assistant Professor of Neurology

ALS therapeutics

 Jeanne M. Nerbonne, Ph.D.
Alumni Endowed Professor of Developmental Biology

Molecular mechanisms controlling the function, expression and properties of voltage-gated K channels in cardiac and neuronal cells

 Karen L. O'Malley, Ph.D.
Professor of Anatomy and Neurology

Mechanisms underlying the specification, regulation, and neurodegeneration of dopaminergic and glutamatergic systems.

 David M. Ornitz, M.D., Ph.D.
Alumni Endowed Professor and Interim Chair of Developmental Biology

FGFs in lung, skeletal, cardiovascular and CNS development and function

 Rohit V. Pappu, Ph.D.
Associate Professor of Biomedical Engineering

Alzheimer’s disease; biophysics; mathematical modeling; thermodynamics

 Alexander Parsadanian, Ph.D.
Research Assistant Professor of Neurology

Role of neurotrophic factors on different aspects of motor neuron neurobiology

 Joel S. Perlmutter, M.D.
Elliot H. Stein Professor of Neurology; Professor of Radiology and Anatomy & Neurobiology; Head of the Movement Disorders Section

Pharmacology, physiology and pathophysiology of basal ganglia and movement disorders.

 Alan Pestronk, M.D.
Professor of Neurology and Pathology; Director of the Neuromuscular Division

Diagnosis, pathogenesis and treatment of immune, hereditary and degenerative neuromuscular disorders

 David R. Piwnica-Worms, M.D., Ph.D.
Professor of Radiology and Developmental Biology

Molecular imaging of gene expression and protein function in vivo; multidrug resistance transporters; metallopharmaceuticals

 Narendrakumar Ramanan, Ph.D.
Assistant Professor of Anatomy & Neurobiology

 Joshua B. Rubin, M.D., Ph.D.
Assistant Professor of Pediatrics

Biology and treatment of pediatric brain tumors

 Shelly E. Sakiyama-Elbert, Ph.D.
Joseph and Florence Farrow Associate Professor of Biomedical Engineering

Tissue and cellular engineering approaches to neurological diseases

 Mark S. Sands, Ph.D.
Associate Professor of Internal Medicine and Genetics

Pathophysiology and novel therapies for lysosomal storage diseases

 Anneliese M. Schaefer, J.D., Ph.D.
Research Assistant Professor of Neurology; Deputy Director of the Hope Center for Neurological Disorders

Pathological changes of axons, motor units, and neuromuscular junctions in motor neuron disease

 Bradley L. Schlaggar, M.D., Ph.D.
Associate Professor of Neurology

The development and plasticity of human cognition and language

 Robert E. Schmidt, M.D., Ph.D.
Professor of Pathology & Immunology; Director, Neuropathology Division

Pathogenetic mechanisms of diabetic and age-related autonomic neuropathy

 Christian T. Sheline, Ph.D.
Research Assistant Professor of Neurology

Mechanisms of zinc-mediated toxicity in neurodegeneration, injury and disease

 B. Joy Snider, M.D., Ph.D.
Assistant Professor of Neurology

Mechanisms of protein degradation and intracellular calcium homeostasis in neurodegenerative disorders

 Sheng-Kwei (Victor) Song, Ph.D.
Associate Professor of Radiology

Development of non-invasive imaging of central nervous system white matter

 Paul H. Taghert, Ph.D
Professor of Anatomy & Neurobiology

Circadian neurobiology and developmental neurobiology

 K. Liu Lin Thio, M.D., Ph.D.
Assistant Professor of Neurology

Glycine receptors in the central nervous system

 Heather L. True-Krob, Ph.D.
Assistant Professor of Cell Biology & Physiology

Protein misfolding and aggregation of prion proteins

 Conrad Chris Weihl, M.D., Ph.D.
Assistant Professor of Neurology

Protein degradation pathways and their relation to aging, muscle weakness, and neurodegeneration

 Michael Wong, M.D., Ph.D.
Assistant Professor of Neurology and Pediatrics

Cellular mechanisms of epileptogenesis and seizure-induced brain injury

 David F. Wozniak, Ph.D.
Research Professor of Psychiatry

Role of NMDA receptors in neuropathologic changes and cognitive decline

 Kelvin A. Yamada, M.D.
Associate Professor of Neurology and Pediatrics

Modulation and derangements of synaptic transmission at central nervous system synapses

 Gregory J. Zipfel, M.D.
Assistant Professor of Neurological Surgery and Neurology

Role of amyloid-β peptide and cerebral amyloid angiopathy in neurovascular dysfunction, ischemic brain injury and subarachnoid hemorrhage

 Charles F. Zorumski, M.D.
Samuel B. Guze Professor and Head of Psychiatry; Professor of Anatomy & Neurobiology

Synaptic development and plasticity related to neural injury