Prions are a new kind of infectious agent thought to be at the heart of several rare neurodegenerative disorders that devastate the brains of humans, cows and sheep. Hope Center members David Harris, M.D., Ph.D. and Heather True-Krob, Ph.D. are gathering new insights into how prions form and cause disease. As they do, tantalizing hints are starting to emerge that prions may be connected to a much wider range of biological phenomena than the rare brain disorders that first led to their discovery.

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