Collaborative seed grant proposals were solicited with the following requirements: 1) involve more than one
laboratory and discipline, 2) address a current scientific focus of the Hope Center, 3) have a clear application
to research translation, and 4) show promise for subsequent independent funding. The projects listed below
exemplified the above criteria for their respective year.

• 2007
  Project 1:
  “Misfolded protein accumulation and neurodegeneration due to phospholipase gene mutations”
  Paul Kotzbauer, MD, PhD
  Joy Snider, MD, PhD
  
  Project 2:
  “Function of FGF14 in progressive spinocerebellar ataxia”
  David Ornitz, MD, PhD
  Kel Yamada, MD
  Jeanne Nerbonne, PhD
  David Wozniak, PhD
  
  Project 3:
  “Microdevice development for the study of axon degeneration and injury”
  Shelly Sakiyama-Elbert PhD
  Karen O’Malley, PhD
  Amy Shen, PhD
  
  Project 4:
  “Development of a Clinically Relevant Mouse Model of Infant Traumatic Brain Injury”
  David Brody, MD, PhD
  Alexander Parsadanian, PhD
  Philip Bayly, PhD
  Krikor Dikranian, MD, PhD
  
  
  
• 2006
  Project 1:
  "Unraveling the amyloid fibril with polyphenols"
  Jin-Moo Lee, MD, PhD
  Carl Frieden, PhD
  John Heuser, MD
  Rohit Pappu, PhD
  David Wozniak, PhD
  
  Project 2:
  "In vivo labeled proteomics in human CSF"
  Randall Bateman, MD
  Donald Elbert, PhD
  Alison Goate, D. Phil
  
  Project 3:
  "Use of hybrid mammalian-yeast prions to identify factors that inhibit protein aggregation"
  David Harris, MD, PhD
  Heather True-Krob, PhD
  
  
  
• 2005
  Project 1:
  "Genetics of Amyotrophic Lateral Sclerosis"
  Alison Goate, D. Phil
  
  Project 2:
  "Inhibitors of Sodium Channels as Axonal Protectants in Experimental Autoimmune Encephalomyelitis"
  Anne Cross, MD
  
  Project 3:
  "Stimulating Axonal Protection in ALS via Activation of Nuclear NAD Biosynthesis"
  Anneliese M. Schaefer, JD, PhD and Jeffrey Milbrandt, MD, PhD